VDR is a gene which codes for a vitamin D receptor protein. This protein regulates calcium absorption and bone growth. A variant of the gene (rs2228570, FokI polymorphism) is associated with decreased bone mineral density among white prepubescent girls.
The hnRNP C1/C2 component of the nuclear vitamin D receptor complex interacts with promoter regions of genes that gescheftmarketing.de/2020/12/22/geschaeftsmarketingstrategie/ are responsive to 1,25-dihydroxyvitamin D3 and can induce their transcription. The interaction is regulated through the reciprocal pattern and temporal on-and-off occupancy of the VDRE between the two components. It is also controlled by chromosomal position and binding preferences for specific hormones. Microarray studies of human cells reveal that more than 100 genes possess a distinct VDRE located in their promoters. The VDRE is occupied by transcription repressors in the absence of 1,25-dihydroxyvitamin D3. The 1,25-dihydroxyvitamin D3-VDR complex binds to these genes, resulting in the recruitment of hnRNP C1/C2 and other proteins that can compete with the repressors and initiate transcription.
A virtual dataroom (VDR) can be a repository of information and documents relevant to business, legal transactions, or processes. Viewing, downloading, or printing are restricted. It makes use of a central server and an extranet connection that is an Internet connection with restricted access, to provide controlled log-on for set time periods during which users are able to view the data and documents.
Companies involved in investment banking and in mergers and acquisitions are the most frequent users of VDRs. VDR. They require an encrypted platform to share information with potential buyers or investors in a transparent way and due diligence could require huge quantities of data. Life science companies also use VDRs to store everything from clinical trial results to HIPAA documentation.
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